Regulation of colony-stimulating factor 1 receptor signaling by the Src-like adaptor protein-2.

by Benjamin Pakuts

Written in English
Published: Pages: 82 Downloads: 870
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The hematopoietic adaptor protein SLAP-2 has been previously characterized as a negative regulator of T cell signaling through its ability to associate with the E3 ubiquitin ligase c-Cbl. Here we describe a specific role for SLAP-2 in regulation of signaling from the colony stimulating factor 1 receptor (CSF-1R), which is important for growth and differentiation of monocyte/macrophage cells. The expression of SLAP-2, but not the closely-related family member SLAP, is upregulated during macrophage differentiation. Furthermore, in myeloid cells expressing CSF-1R (FD-Fms cells) SLAP-2 appears to be tyrosine phosphorylated upon stimulation of the receptor and associates constitutively with both c-Cbl and CSF-1R in vivo. Using stable overexpression of SLAP-2, it was found that SLAP-2 affected CSF-1R-mediated differentiation, and caused an accumulation of ubiquitinated CSF-1R by modulating the association between c-Cbl and the receptor. Taken together, these results support an important role for SLAP-2 in the regulation of CSF-1R signaling.

The Physical Object
Pagination82 leaves.
Number of Pages82
ID Numbers
Open LibraryOL19215709M
ISBN 100494025166

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Regulation of colony-stimulating factor 1 receptor signaling by the Src-like adaptor protein-2. by Benjamin Pakuts Download PDF EPUB FB2

The colony-stimulating factor 1 receptor (CSF-1R) 4 is a member of the type III receptor tyrosine kinase (RTK) family, which includes c-Kit, platelet-derived growth factor receptor α and β, and Flt3 ().All of the functions of colony-stimulating factor-1 (CSF-1) are mediated by CSF-1R, which is the primary regulator of the common myeloid lineage consisting of.

The Role of the Src-like Adaptor Protein in the Regulation of GM-CSFR Signaling Sarah Di Clemente Master of Science Department of Medical Biophysics University of Toronto Abstract GM-CSF is a cytokine that regulates proliferation and survival of myeloid progenitor cells and stimulates dendritic cell (DC) : Sarah Di Clemente.

Benjamin Pakuts has written: 'Regulation of colony-stimulating factor 1 receptor signaling by the Src-like adaptor protein-2'. The colony-stimulating factor-1 (CSF-1) receptor (CSF-1R), encoded by the protooncogene c-fms, is the cell surface receptor for the macrophage colony-stimulating is a member of the tyrosine kinase family of growth factor receptors, which are believed to exert their biological influence through the catalysis of tyrosine phosphorylation of key intracellular by: 6.

Src-like adaptor protein 2 (SLAP2) was initially identified as an inhibitory protein of antigen receptor-mediated activation of lymphocytes (Holland et al. ).The SLAP family of proteins consists of two members, SLAP and SLAP2.

Request PDF | On Jan 1,Sausan A. Moharram and others published Src-Like Adapter Protein 2 (SLAP2) | Find, read and cite all the research you need on ResearchGate. Where is colony stimulating factor produced. We need you to answer this question. If you know the answer to this question, please register to join our limited beta program and start the.

Cbl (named after Casitas B-lineage Lymphoma) is a mammalian gene encoding the protein CBL which is an E3 ubiquitin-protein ligase involved in cell signalling and protein ons to this gene have been implicated in a number of human cancers, particularly acute myeloid s: CBL, C-CBL2, FRA11B, NSLL, RNF55, Cbl.

Signaling via the epidermal growth factor (EGF)-receptor family is subject to regulation and modulation by multiple ligands, effectors and negative regulators, as well as regulation by. Tyrosine kinases (TKs) phosphorylate proteins on tyrosine residues as an intracellular signalling mechanism to coordinate intestinal epithelial cell communication and fate decision.

Deregulation of their activity is ultimately connected with carcinogenesis. In colorectal cancer (CRC), it is still unclear how aberrant TK activities contribute to tumour formation because TK-encoding genes Cited by: 1. The differentiation of pDCs from CDPs appears to require high levels of expression of the E protein (E) transcription factor.

10,57 Human pDC-lineage cells have a characteristic surface phenotype of high expression of the IL-3 receptor α chain (CD), low but detectable expression of CD4, and lack of immunoglobulin-like transcript 1. CBL (gene): | | | Cbl proto-oncogene, E3 ubiquitin protein ligase | | World Heritage Encyclopedia, the aggregation of the largest online encyclopedias available, and the most definitive collection ever assembled.

BACKGROUND:The purpose of this study was to identify transcripts of retinal rod photoreceptors of the zebrafish. The zebrafish is an important animal model for vision science due to rapid and tractable development, persistent neurogenesis of rods throughout the lifespan, and capacity for functional retinal regeneration.

Functional cooperation between c-Cbl and Src-like adaptor protein 2 in the negative regulation of T-cell receptor signaling. Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a transmembrane glycoprotein that is expressed on epithelial, endothelial and immune cells.

CEACAM1 is a differentiation antigen involved in the maintenance of epithelial polarity that is induced during hepatocyte differentiation and liver regeneration. CEACAM1 regulates insulin sensitivity by Cited by: 8. Receptor Tyrosine Kinases: Family and Subfamilies.

Download PDF. 4 downloads 25 Views 16MB Size Report. Comment. Thomas Prébet Centre de Recherche en Cancérologie de Marseille, Inserm. U A PDZ Domain Protein Interacts with the C-terminal Tail of the Insulin-like Growth Factor-1 Receptor but Not with the Insulin Receptor.

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David J. Matthews Mary E. Gerritsen - Targeting Protein Kinases for Cancer Therapy () код для вставки. Genes whose expression is correlated with and determinant of an atherosclerotic phenotype are provided. Genes whose expression is correlated with and determinant of an atherosclerotic susceptibility are also provided.

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The present invention includes an apparatus, system and method for the development and use of transcriptional modules by obtaining Cited by:   What is claimed is: 1.

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